A battle royale between superhumans takes place for the title of X, the most popular hero.

Follows Rouge, an android girl, who is on a mission on Mars with her partner Naomi. The mission is to murder Immortal Nine, nine artificial humans who are hostile to the government.

Várias gerações da família Joestar enfrentam vilões sobrenaturais ao longo dos tempos, sempre com o mesmo apelido.